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KMID : 0376219830200030495
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Chonnam Medical Journal
1983 Volume.20 No. 3 p.495 ~ p.500
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Selective Coronary Arterial Infusion of Cardioplegic Solution. -An Experimental Study in Six Dogs
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Abstract
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Conventional transaortic administration of cardioplegic solution result in regional discrepancies in myocardial temperatures in patients with severe coronary artery disease. This regional discrepancies in myocardial temperature may result in non-uniform and inadequate levels of myocardial protection.
This study was designed to determine the effect of the transaortic infusion of cardioplegic solution with selective coronary arterial cardioplegic solution. Using an experimental model of critical stenosis of the circumflex coronary artery, the effectiveness of this technique was compared with that of conventional transaortic infusion technique.
Three experimental condition of cardioplegic solution administration were evaluated in each animal, (1) 500ml of solution infused into the aortic root; (2) 1000 ml infused into the aortic root; (3) 500 ml infused into the aortic root followed by an additional 100 infused directly into the circumflex coronary artery cannula distal to the stenosis. Temperature were measured into the left ventricular wall in the distribution of both the CCA and LAD artery.
Significant regional temperature gradient "generated by transaortic infusion of 500 of CPS(9.5±1.95°C) was still evident with the transaortic infusion of 1000 of CPS(5.9±2.25°C). These gradients were uniformly eliminated by the selective infusion of 100 of CPS into the CCA cannula distal to the stenosis (-0.9±2.10°C)
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